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Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan
Kuo-Liang Chiu1,2, Guan-Liang Chen3,4, Chia-Hsiang Li5,6,7
1Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.
In Vivo (Athens, Greece)
|August 28, 2025
Summary
The MMP-7 -181A>G polymorphism is not a primary risk factor for asthma. However, the G allele may indicate a higher likelihood of developing severe asthma, particularly in younger Taiwanese adults.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Asthma is a complex respiratory condition influenced by genetic factors.
- The matrix metalloproteinase-7 (MMP-7) gene promoter polymorphism -181A>G (rs11568818) is investigated for its role in asthma.
Purpose of the Study:
- To examine the association between the MMP-7 -181A>G polymorphism and asthma susceptibility and severity.
- To identify potential genetic markers for asthma risk in a Taiwanese population.
Main Methods:
- Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping was used.
- The study included 198 asthma patients and 453 healthy controls from Taiwan.
Main Results:
- No significant overall association was found between MMP-7 genotypes and asthma risk.
- A borderline significance was observed for the G allele (OR=1.44, p=0.0950).
- The AG genotype was associated with increased asthma risk in individuals aged 25-40 years (OR=1.86, p=0.0365).
- Genotype distribution significantly correlated with asthma severity (p for trend=0.0040), with AG and GG genotypes linked to more severe symptoms.
Conclusions:
- The MMP-7 -181A>G polymorphism is not a major susceptibility marker for asthma.
- The G allele may serve as a potential biomarker for younger-onset and more severe asthma phenotypes in Taiwanese individuals.
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