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Prediction-powered inference for clinical trials: application to linear covariate adjustment

Pierre-Emmanuel Poulet1, Maylis Tran1, Sophie Tezenas du Montcel1

  • 1ARAMIS, Sorbonne Université, Paris, France.

BMC Medical Research Methodology
|August 28, 2025
PubMed
Summary

Prediction-powered inference (PPI) enhances clinical trials by creating digital twins for patients, reducing sample size and control group needs. This statistically valid method improves treatment effect estimation in randomized clinical trials.

Keywords:
Average treatment effectClinical trialsEmpowered estimatorPrognostic factorSample size reductionStatistical test

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