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Updated: Sep 9, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-light-induced energy-transfer-mediated hydroacylation of alkenes with alcohol-derived oximes
Abstract:
Herein, we report a visible light-driven hydroacylation strategy for the efficient synthesis of 1,4-ketoesters from alkenes and alcohol-derived oximes under mild conditions. The reaction proceeds via an energy transfer (EnT)-mediated pathway, wherein homolytic N-O bond cleavage generates alkoxy radicals that serve as key intermediates for subsequent radical addition to alkenes. This method features a broad substrate scope and high functional group tolerance, and delivers 1,4-ketoesters in good yields.
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