Access to Pyrrolo- and Dihydropyrrolofuranthridones via Phosphine-Mediated MBH-Type/O-Acylation/Wittig Reaction
Raghunath Maruti Walunj1, Yadav Kacharu Nagare1, Gangababu Marri1
1Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, R.O.C.
Abstract:
We disclose phosphine-mediated double annulation via a one-pot reaction for the construction of functionalized pyrrolofuranthridones. This one-pot protocol involves a Morita-Baylis-Hillman (MBH)-type/O-acylation/Wittig reaction sequence. Broad functional group tolerance is displayed, and a range of pyrrolofuranthridones are obtained in good to high yields. Furthermore, this methodology has been successfully extended to indoline N-alkynamides as substrates for the synthesis of dihydropyrrolofuranthridones in high yields.
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