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Updated: Sep 9, 2025
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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
707
[Cardiogenic dementia]
R G Esin1,2, E A Gorobets1, A I Mashtakova1
1Kazan Federal University, Kazan, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 29, 2025
Summary
Heart disease significantly contributes to cerebrovascular disorders like cognitive impairment and dementia. Understanding these links is crucial for better diagnosis and prevention strategies.
Area of Science:
- Neurology
- Cardiology
- Gerontology
Background:
- Cerebrovascular disease discussions often focus on arteries, overlooking the heart's critical role.
- Heart conditions are significant, often dominant, contributors to cerebrovascular disorders, including cognitive impairment and dementia.
- The arbitrary separation of cardiovascular and cerebrovascular disease management hinders comprehensive patient care.
Purpose of the Study:
- To review the literature on the role of heart disease in cognitive impairment and dementia.
- To explore the concept of "cardiogenic dementia" and its underlying mechanisms.
- To highlight the importance of considering cardiac health in cerebrovascular disease management.
Main Methods:
- A comprehensive literature review was conducted over a 50-year period.
- Searches were performed in major scientific databases: eLibrary.ru, CyberLeninka, PubMed, Scopus, and Google Scholar.
- Key search terms included "myocardial infarction," "heart failure," "myocardial disease," "cognitive impairment," and "dementia."
Main Results:
- Evidence supports a broader understanding of "cardiogenic dementia" pathogenesis, a concept introduced nearly 50 years ago.
- Mechanisms include chronic brain hypoperfusion, low-grade inflammation, oxidative stress, and blood-brain barrier damage.
- Renin-angiotensin-aldosterone and sympathetic nervous system hyperactivation are implicated in myocardial disease-related encephalopathy.
Conclusions:
- Heart diseases play a pivotal role in the development of cognitive impairment and dementia.
- Recognizing "cardiogenic dementia" necessitates integrated approaches to cardiovascular and neurological care.
- Further research into shared etiological pathways can improve prevention and treatment strategies.
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