Related Experiment Video
Updated: Sep 9, 2025
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in Parkinson's Disease: Real-World Short-Term Data on
Katarina Rukavina1, Georg Ebersbach1, Doreen Gruber1,2,3
1Movement Disorders Hospital Beelitz, Beelitz-Heilstätten, Germany.
Background:
Foslevodopa/foscarbidopa (LDp/CDp) significantly reduced motor fluctuations in people with Parkinson's disease (PwP) in clinical trials, but its real-world tolerability and optimal dosing remain unclear.
Objectives:
To assess tolerability, dosing patterns, and modifications to concomitant medication with LDp/CDp in clinical practice.
Methods:
A single-center retrospective cross-sectional analysis.
Results:
The LDp/CDp was initiated in 53 PwP (41% women, mean age 66 ± 11.3 years, mean disease duration 14.1 ± 5.7 years, median H&Y 4 (3-5); history of cognitive impairment: 40%, history of psychosis: 62%, previous device aided therapies failure: 39%). After an optimization period (18.4 ± 6.8 days), the mean Base hourly infusion rate was significantly higher than recommended (0.39 ± 0.18 vs. 0.32 ± 0.13 ml/h, p < 0.001) and the LDp/CDp was co-administered with MAO-B-inhibitors (50%), COMT-inhibitors (44%), and dopamine agonists (12%). Adverse events occurred in 40%: skin reactions (31%), psychosis (8%), falls (2%), and nausea (2%). Thirteen patients discontinued therapy.
Conclusions:
LDp/CDp may be an effective and well-tolerated non-surgical option for managing motor fluctuations in PD, though higher dosing and combination therapy are often required.
Related Concept Videos
01:24Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
01:15Parkinson's Disease: Overview
01:30Continuous Renal Replacement Therapy
01:29Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:01Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...