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Skeletal Muscle as Endocrine Organ
Mei Ma1, Ziyi Zhang1, Hai Bo1,2
1Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of Exercise and Health, Tianjin University of Sport, Tianjin, China.
Advances in Experimental Medicine and Biology
|August 29, 2025
Summary
Skeletal muscle acts as an endocrine organ, releasing myokines that benefit health. Exercise boosts myokine production, highlighting muscle
Area of Science:
- Exercise physiology
- Endocrinology
- Muscle biology
Background:
- Skeletal muscle is recognized as an endocrine organ.
- It synthesizes and secretes myokines, influencing other organs.
- Physical activity stimulates myokine production.
Purpose of the Study:
- Review myokine types and functions.
- Examine exercise effects on myokine expression.
- Highlight skeletal muscle's endocrine role in health and disease prevention.
Main Methods:
- Literature review of myokine research.
- Analysis of exercise's impact on myokine signaling.
- Exploration of clinical implications.
Main Results:
- Myokines mediate communication between muscle and organs like liver, fat, and brain.
- Exercise-induced myokines improve metabolism, cognition, and bone health.
- Limited understanding of human myokine functions exists.
Conclusions:
- Skeletal muscle's endocrine function is crucial for health.
- Myokines hold potential as biomarkers for exercise and disease management.
- Further research is needed to explore clinical significance and future directions.
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