A Comprehensive Bibliometric and Visual Analysis of EGR1 in Cardiovascular Disease

Early Growth Response 1 (EGR1) is a crucial transcription factor that regulates diverse cellular processes, including growth, differentiation, proliferation, inflammation, apoptosis, and autophagy. It plays a vital role in maintaining cardiac homeostasis and is deeply implicated in the pathological mechanisms leading to cardiomyocyte death, making it a promising therapeutic target for cardiovascular diseases. To better understand the research landscape of EGR1 in this context, we conducted a bibliometric analysis using data from the Web of Science Core Collection (WoSCC) covering the period from 2014 to 2024, retrieved on 31 December 2024. A total of 2,112 publications related to EGR1 were identified, of which 173 specifically addressed cardiovascular disease and were published across 126 journals. Global research output on this topic has shown fluctuating growth over the past decade, with China contributing the most publications and citations. The Institut national de la santé et de la recherche médicale (Inserm) emerged as the most productive institution. Zhang Y authored the highest number of papers, while Wang J received the most citations. Scientific Reports was the most prolific journal, whereas the Journal of Biological Chemistry was the most influential in terms of citation metrics. Keyword co-occurrence and cluster analysis revealed major research themes such as apoptosis, inflammation, oxidative stress, angiogenesis, and autophagy. These findings provide a comprehensive overview of EGR1-related cardiovascular research and offer a valuable reference for future investigations into its mechanisms and therapeutic potential.