Related Experiment Video

Updated: Sep 9, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.7K

Self-Measured Home Orthostatic Hypo- and Hypertension-Prevalence and Associations With Atherosclerosis and Arterial

F Frey1, P Af Geijerstam2, F Iredahl2,3

  • 1Department of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linkoping University, Norrköping, Sweden.

American Journal of Hypertension
|August 30, 2025
PubMed

Insights

Self-measured home orthostatic hypotension and hypertension are linked to atherosclerosis markers. Home orthostatic hypotension also relates to arterial stiffness, highlighting the importance of monitoring blood pressure at home.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Public Health

Background:

  • In-office orthostatic blood pressure (BP) dysregulation is a known cardiovascular risk predictor.
  • The prevalence and atherosclerotic associations of home-measured orthostatic BP reactions are not well-established in large populations.

Purpose of the Study:

  • To investigate the prevalence of home orthostatic hypotension (home OH) and home orthostatic hypertension (home OHT).
  • To examine the association of home OH and home OHT with markers of atherosclerosis, including carotid plaques, pulse wave velocity (PWV), and coronary artery calcium score (CACS).

Main Methods:

  • Cross-sectional analysis of 4556 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS).
  • Home BP measurements included two standing BP readings using an Omron M10-IT device.
  • Home OH defined as systolic BP drop ≥20 mmHg or diastolic BP drop ≥10 mmHg upon standing. Home OHT defined as systolic BP increase ≥20 mmHg upon standing.

Main Results:

  • 6.4% of participants had home OH (n=293) and 3.1% had home OHT (n=139).
  • Participants with home OH or home OHT showed higher prevalence of carotid plaques compared to those with normal reactions (65.5% and 64.7% vs. 55.3%).
  • Home OH was associated with higher PWV (9.2±1.4 vs. 8.9±1.3 m/s) and increased likelihood of CACS ≥100 (17.4% vs. 11.6%). No significant associations were found for home OHT with PWV or CACS.

Conclusions:

  • Self-measured home orthostatic hypotension and hypertension are associated with subclinical atherosclerosis.
  • Home orthostatic hypotension specifically is linked to arterial stiffness, suggesting its clinical relevance beyond simple BP drops.
Abstract

Keywords:
atherosclerosisblood pressurecarotid plaquescoronary calcium scorehome blood pressurehypertensionorthostatic blood pressureorthostatic hypertensionorthostatic hypotensionpulse wave velocity

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.1K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.1K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
38
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K
Special considerations while measuring blood pressure01:28

Special considerations while measuring blood pressure

When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
822
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.5K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
77