Chromoplexy
Franck Pellestor1,2, Jean Baptiste Gaillard3, Benjamin Ganne3,4
1Unit of Chromosomal Genetics and Research Platform Chromostem, Department of Molecular Genetics and Cytogenomics, Site Unique de Biologie (SUB), Montpellier CHU, Montpellier Cedex 5, France. f-pellestor@chu-montpellier.fr.
Methods in Molecular Biology (Clifton, N.J.)
|August 30, 2025
Summary
Chromoplexy, a complex chromosomal rearrangement, causes gene fusions and disruptions in cancer. This massive genomic event, occurring early in oncogenesis, drives tumor evolution and progression.
Area of Science:
- Genomics
- Cancer Biology
- Molecular Oncology
Background:
- Chromoplexy is a complex genomic rearrangement involving multiple chromosomes.
- It leads to gene fusions and disruptions, observed in various cancers, including prostate cancer.
- The precise mechanisms of chromoplexy formation remain largely unknown.
Purpose of the Study:
- To elucidate the mechanisms underlying chromoplexy formation.
- To understand the role of chromoplexy in oncogenesis and tumor progression.
- To investigate the genomic configurations associated with chromoplexy.
Main Methods:
- Analysis of complex chromosomal rearrangements in cancer genomes.
- Identification of double-stranded break patterns in specific genomic contexts.
- Characterization of inter- and intra-chromosomal translocations and deletions.
Main Results:
- Chromoplexy involves extensive chromosomal rearrangements without significant copy number alterations.
- These rearrangements are linked to specific genomic configurations like open chromatin and active transcription.
- Chromoplexy can occur early in cancer development and contribute to clonal evolution.
Conclusions:
- Chromoplexy is a significant driver of genomic instability in cancer.
- It supports models of punctuated tumor evolution with rapid genomic alterations.
- Further research is needed to fully understand and potentially target chromoplexy mechanisms.
Keywords:
ChromoanagenesisChromoplexyDeletionGene fusionProstate cancerPunctuated evolutionTranslocationTumorMore Related Videos
Related Concept Videos
01:11Channel Rhodopsins
2.6K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.6K
01:22Photoreceptors and Visual Pathways
6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
01:26Photochemical Electrocyclic Reactions: Stereochemistry
1.9K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
1.9K
01:24Color Vision
695
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
695
01:20Anatomy of the Eyeball
7.6K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.6K
01:26Phase Contrast and Differential Interference Contrast Microscopy
9.4K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
9.4K