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Updated: Sep 9, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
TGF-β signaling as an organismal proteostasis regulator
Huadong Zhu1, Qian Zhang2, Ye Tian3
1Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada (IMRIC), The Faculty of Medicine of the Hebrew University of Jerusalem, Ein Kerem, Jerusalem 9112102, Israel.
Abstract:
Various mechanisms act in a coordinated manner to maintain proteostasis in different cellular organelles. Nevertheless, with aging, certain proteins escape proteostasis surveillance, misfold, and aggregate. This process can lead to neurodegeneration. Despite the cellular nature of proteostasis, it is regulated by intertissue communication. How these intertissue signaling mechanisms coordinate proteostasis across the organism is largely obscure. Recent studies unveiled that the transforming growth factor (TGF)-β signaling cascade is an organismal proteostasis regulator. Here, we focus on the known roles of the TGF-β pathway as a coordinator of proteostasis and describe the messengers and biological activities that are controlled by this pathway. We also discuss open questions and highlight the potential clinical relevance of these discoveries.
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