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Updated: Sep 9, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Circular RNAs in Liver Diseases
Archittapon Nokkeaw1,2,3, Chaiyaboot Ariyachet4,5
1Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Advances in Experimental Medicine and Biology
|August 31, 2025
Summary
Circular RNAs (circRNAs), stable noncoding RNAs formed by back-splicing, regulate gene expression and are implicated in liver disease. Understanding circRNAs offers new diagnostic and therapeutic strategies for liver disorders.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Circular RNAs (circRNAs) are a distinct class of noncoding RNAs.
- They are formed via back-splicing, conferring high stability against degradation.
- circRNAs play roles in gene regulation, protein interaction, and translation.
Purpose of the Study:
- To review the role of circRNAs in liver disease pathogenesis.
- To explore the diagnostic and therapeutic potential of circRNAs in liver disorders.
- To consolidate understanding of circRNA regulatory networks in liver pathophysiology.
Main Methods:
- Literature review of current research on circRNAs and liver disease.
- Analysis of circRNA mechanisms in gene expression regulation.
- Examination of diagnostic and therapeutic applications.
Main Results:
- circRNAs are involved in various gene regulatory mechanisms, including splicing modulation and miRNA sponging.
- Their stability and diverse functions highlight their significance in disease.
- circRNAs show promise as biomarkers and therapeutic targets in liver diseases.
Conclusions:
- circRNAs are crucial regulators in liver pathophysiology.
- Further research into circRNAs can lead to advancements in precision medicine for liver disease.
- circRNAs present significant potential for diagnostic and therapeutic innovations.
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