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Updated: May 11, 2026
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
An ex vivo human placental explant model for controlled exposure studies
Nida Ozarslan1, Lin Li1, Sirirak Buarpung2
1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Abstract:
The human placental explant model preserves the placenta's natural structure, enabling studies on whole-tissue response to exposures or growth conditions. It outlines procedures for placental collection, isolation, and culturing, followed by exposure to conditions of interest. Additionally, it details sample collection of explant tissue and culture supernatant after exposure for downstream assessments of placental function. This protocol provides a framework for evaluating ex vivo responses of human placental tissue. For complete details on the use and execution of this protocol, please refer to Gonzalez et al.1.
