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Radiation Recall Dermatitis Following Capivasertib Administration.

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|August 31, 2025
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Summary
This summary is machine-generated.

Radiation recall dermatitis occurred in a patient treated with capivasertib, a PI3K/Akt pathway inhibitor, for metastatic breast cancer. This rare adverse effect highlights the need for caution when using capivasertib in patients with prior radiation therapy.

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Radiation recall dermatitis is a rare adverse effect.
  • Capivasertib is a PI3K/Akt pathway inhibitor approved for breast cancer.
  • Its safety with palliative radiation is unknown.

Purpose of the Study:

  • To report a case of radiation recall dermatitis.
  • To discuss capivasertib's safety in patients with prior radiation.

Main Methods:

  • Case report of a metastatic breast cancer patient.
  • Patient received capivasertib after prior radiation to the lower extremity.

Main Results:

  • The patient developed radiation recall dermatitis.
  • Treatment included corticosteroids, antibiotics, and switching to alpelisib.

Conclusions:

  • Capivasertib may trigger radiation recall dermatitis.
  • Caution is advised when using capivasertib in patients with prior radiation history.