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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Three Developmental Domains01:29

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Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
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Clearance Models: Physiological Models01:09

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Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Updated: Sep 9, 2025

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Physiological aging in three dimensions.

Fei Ma1, Ranjan Sen1

  • 1Gene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.

Trends in Cell Biology
|August 31, 2025
PubMed
Summary
This summary is machine-generated.

Aging alters three-dimensional (3D) chromatin organization, impacting gene expression and cellular function. This review explores age-related changes in 3D genome structures and their links to aging and senescence.

Keywords:
3D chromatin structureagingenhancer–promoter interactionepigenomesenescencetranscription regulation

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Area of Science:

  • Epigenetics and Molecular Biology
  • Genomics and Bioinformatics
  • Cellular Aging and Gerontology

Background:

  • Aging involves progressive decline driven by epigenetic changes, including DNA methylation and histone modifications.
  • Three-dimensional (3D) chromatin organization, crucial for gene regulation, is an underexplored aspect of aging.
  • Chromosome conformation capture technologies reveal hierarchical structures like compartments, TADs, and loops.

Purpose of the Study:

  • To review recent findings on age-associated reorganization of 3D chromatin structures.
  • To highlight the impact of these structural changes on gene transcription and nuclear architecture.
  • To compare 3D chromatin organization in aging versus senescence, identifying shared and distinct features.

Main Methods:

  • Literature review of recent studies on 3D genome organization and aging.
  • Analysis of data from chromosome conformation capture (3C) based technologies.
  • Comparative analysis of aging and senescence contexts regarding chromatin structure.

Main Results:

  • Emerging evidence indicates that aging alters 3D chromatin structures, including compartments, TADs, and loops.
  • These age-associated structural changes correlate with altered gene expression patterns and cellular dysfunction.
  • Specific alterations in nuclear architecture are observed with advancing age.

Conclusions:

  • Age-related changes in 3D chromatin organization significantly impact cellular function and organismal aging.
  • Understanding these structural dynamics is key to deciphering aging mechanisms and developing interventions.
  • Shared and distinct roles of 3D chromatin organization exist in aging and cellular senescence.