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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Updated: Sep 9, 2025

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Targeting immunosenescence and inflammaging: advancing longevity research.

Thi Quynh Trang Nguyen1,2, Kyung A Cho3,4,5

  • 1Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Republic of Korea.

Experimental & Molecular Medicine
|August 31, 2025
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The immune system

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Area of Science:

  • Immunology and Gerontology
  • Cellular and Molecular Biology

Background:

  • Aging is associated with a decline in immune function, known as immunosenescence.
  • Chronic low-grade inflammation, termed inflammaging, also characterizes aging and contributes to age-related diseases.

Purpose of the Study:

  • To provide a comprehensive overview of factors contributing to immune system aging.
  • To introduce therapeutic strategies for restoring immune function and modulating immune balance.
  • To explore the potential of immune regulation in extending healthspan and promoting longevity.

Main Methods:

  • Literature review and synthesis of current research on immunosenescence and inflammaging.
  • Analysis of therapeutic interventions targeting immune aging.
  • Discussion of systemic immune modulation strategies.

Main Results:

  • Identified key factors driving immune aging, including cellular senescence and chronic inflammation.
  • Highlighted therapeutic approaches that can partially reverse immune decline.
  • Emphasized the importance of systemic immune balance for overall aging processes.

Conclusions:

  • Regulating the immune system is critical for managing immune aging.
  • Modulating immune balance offers a promising avenue for extending healthspan and promoting healthy longevity.