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Updated: Sep 9, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
Non-coding RNAs as key player in cancer diagnosis and treatment
1Department of Transplantation, Institute of Pediatrics, Jagiellonian University, Krakow, Poland.
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Most of the human genome is transcribed into noncoding RNAs (ncRNAs), which although do not encode proteins, are often involved in key cellular processes. Recent technological advances have accelerated the discovery of ncRNA as well as our understanding of ncRNAs as cancer biomarkers and targets. In this "In the Limelight" special issue of FEBS Open Bio, four review articles by leading experts provide an overview of the role of ncRNAs in cancer, from their association to liver cancer to their role as oncogenes in head and neck squamous cell carcinoma (HNSCC).
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