Related Experiment Video
Updated: Sep 9, 2025

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression
Qingqing Han1,2, Nan Chen2, Kun Peng3
1Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150000, China.
Abstract:
Hyperuricemia (HUA) is a prevalent metabolic disorder, with limited therapeutic options. This study investigated the effects and mechanisms of urolithin C (UroC), a gut-microbiota-derived bioactive metabolite from ellagitannin-rich foods, in the management of HUA. In HUA mice, UroC significantly reduced serum uric acid (SUA) levels, outperforming its analogs, UroA and UroB. UFLC-MS/MS identified free UroC as the primary active form in vivo. Mechanistically, UroC alleviated HUA by enhancing renal UA excretion, while concurrently ameliorating renal oxidative stress and fibrosis. Moreover, UroC inhibited UA-induced p38/ERK MAPK activation by reducing the level of reactive oxygen species (ROS) production. Rescue experiments further confirmed that UroC improved the expression of renal UA transporters and fibrosis markers via p38/ERK MAPK inhibition. These findings highlight UroC as a promising food-derived candidate for HUA management, promoting renal protection and enhancing UA excretion via the ROS-p38/ERK MAPK axis.
Related Concept Videos
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Urinary Tract Calculi VI: Surgical Management
Urinary Tract Calculi V: Nursing Management
Urinary Tract Calculi I: Introduction

