Related Experiment Video
Updated: Aug 6, 2026
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Feasibility of early detection of left ventricular diastolic dysfunction in hypertensive patients using
Kun Peng1, Jiang Zhao1, Zijian Wang1
1From the Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China.
Insights
Four-dimensional flow cardiac magnetic resonance (4D flow CMR) can detect early left ventricle diastolic dysfunction (LVDD) in hypertension (HTN). The kinetic energy (KE) E/A ratio shows diagnostic accuracy comparable to traditional methods, even without left ventricular hypertrophy (LVH).
Area of Science:
- Cardiology
- Medical Imaging
- Biophysics
Background:
- Hypertension (HTN) can lead to early left ventricle diastolic dysfunction (LVDD).
- Left ventricular hypertrophy (LVH) is a common complication of HTN.
- Detecting early LVDD is crucial for managing HTN and preventing cardiovascular events.
Purpose of the Study:
- To evaluate the efficacy of four-dimensional flow cardiac magnetic resonance (4D flow CMR) in detecting early LVDD in patients with HTN.
- To assess if 4D flow CMR can identify LVDD irrespective of the presence or absence of LVH.
- To compare the diagnostic performance of 4D flow CMR-derived kinetic energy (KE) parameters with conventional echocardiographic assessments.
Main Methods:
- Retrospective analysis of 66 HTN patients and 30 healthy controls.
- Classification of HTN patients into LVH/non-LVH and LVDD/non-LVDD subgroups based on echocardiography.
- Calculation and indexing of 4D flow CMR-derived LV KE parameters (KEiEDV, KE E/A ratio, in-plane KE, TD).
- Comparison of KE parameters across groups and ROC curve analysis for LVDD detection.
Main Results:
- HTN patients exhibited significantly altered KE patterns compared to controls.
- The KE E/A ratio derived from 4D flow CMR showed high diagnostic accuracy (AUC 0.801-0.805) for LVDD detection in HTN patients, including those without LVH.
- This accuracy was comparable to the echocardiographic parameter E/e' (AUC 0.810).
Conclusions:
- 4D flow CMR-derived KE E/A ratio is a valuable tool for detecting early LVDD in HTN patients.
- This method is effective even in the absence of LVH.
- 4D flow CMR offers a promising non-invasive approach for assessing diastolic function in hypertensive individuals.
Objectives:
To identify whether early left ventricle diastolic dysfunction(LVDD) in hypertension (HTN), with or without left ventricular hypertrophy (LVH), can be detected by four-dimensional flow cardiac magnetic resonance (4D flow CMR).
Methods:
Sixty-six HTN patients and thirty age-/gender matched healthy controls were retrospectively analyzed. The HTN patients were divided into the LVH and non-LVH subgroup, and were further divided into LVDD and non-LVDD subgroup according to a multiparametric echocardiographic assessment incorporating E/e', E/A ratio, and LA diameter(LAd). 4D flow-derived left ventricular (LV) kinetic energy (KE) parameters were calculated and indexed to LV end-diastolic volume (EDV), including KEiEDV during systole, early diastole, and late diastole, as well as in-plane KE(%) and the time difference (TD) of peak E-wave KE propagation. KE parameters were compared among healthy controls, HTN patients with LVDD, and HTN patients without LVDD, as well as between LVH and non-LVH subgroups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of KE parameters for detecting LVDD.
Results:
HTN patients showed significantly altered KE patterns compared with controls, characterized by decreased E-wave KEiEDV and KE E/A ratio and increased A-wave KEiEDV, in-plane KE(%), and TD (all P < 0.01), with similar findings in the non-LVH subgroup. For LVDD detection, the KE E/A ratio demonstrated the best diagnostic accuracy among all evaluated KE and conventional CMR parameters, with an AUC of 0.801 in the overall HTN cohort and 0.805 in the non-LVH subgroup, comparable to E/e' (AUC = 0.810).
Conclusions:
The KE E/A ratio derived from 4D flow CMR is comparable to E/e' for detecting early LVDD in HTN patients, and remains effective even in the absence of LVH.
More Related Videos
11:13Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
11:16In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022