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Zijiang Zhang1, Yanchun Li1, Haofei Hong1

  • 1The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. zwu@jiangnan.edu.cn.

Chemical Communications (Cambridge, England)
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A nanobody chimera composed of an EGFR-targeting nanobody and the LOOP1 peptide derived from HBV surface antigen is capable of harnessing HBV vaccine-induced immunity for cancer immunotherapy.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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