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Updated: Sep 9, 2025
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
[Line-field confocal optical coherence tomography in keratinocyte cancer and margin delineation in basal cell
Marco Mozaffari1, Kristina Fünfer1, Julia Welzel1
1Klinik für Dermatologie und Allergologie, Universitätsklinikum Augsburg Medizincampus Süd, Sauerbruchstr. 6, 86179, Augsburg, Deutschland.
Background:
The number of patients with keratinocyte tumors is steadily increasing. In addition, personnel and procedural costs for surgical treatment are also rising.
Objectives:
How suitable are modern, noninvasive dermatological imaging devices for improving the efficiency of tumor diagnostics and therapy in keratinocyte skin cancer, thereby enhancing treatment outcomes?
Materials And Methods:
Description of the process using a patient pathway and case studies, with discussion of existing literature and future perspectives.
Results And Discussion:
Modern noninvasive imaging techniques such as line-field confocal optical coherence tomography (LC-OCT) offer promising approaches in the surgical treatment of keratinocyte skin cancer, enabling high-resolution real-time tumor diagnostics. Early studies show that LC-OCT can be used both for early diagnosis without biopsy and for preoperative margin delineation of basal cell carcinomas. These techniques allow for efficiency-enhancing concepts in modern tumor therapy. However, clinical data on the practicability of these methods are currently lacking, highlighting the urgent need for validated studies for critical evaluation.
Conclusion:
Noninvasive imaging can increase the efficiency of diagnosis and treatment of keratinocyte tumors through early and rapid diagnosis as well as artificial intelligence-assisted surgical planning.
