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Mandibular Metastatic Breast Cancer: A Rare Case Report with Diagnostic Challenge
Mohammad Mehdizadeh1, Ali Lotfi2, Saede Atarbashi-Moghadam2
1Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical Sciences, Qom, Iran.
Journal of Dentistry (Shiraz, Iran)
|September 2, 2025
Summary
Metastatic breast cancer in the jawbone is rare and challenging to diagnose. This case highlights the importance of patient history, immunohistochemistry, and tumor markers for accurate diagnosis of jawbone metastases.
Area of Science:
- Oncology
- Oral Pathology
- Radiology
Background:
- Jawbone metastatic lesions present diagnostic challenges due to rarity and varied characteristics.
- Early detection and accurate diagnosis are crucial for effective patient management.
Observation:
- A 57-year-old female presented with lower face swelling, revealing a mandibular lesion on CBCT.
- The patient had a history of breast cancer diagnosed six years prior.
Findings:
- Histopathology showed malignant small round cells, with IHC positive for cytokeratin (CK) and GATA3.
- Elevated CA15-3 tumor marker levels confirmed metastatic breast carcinoma.
- Imaging confirmed isolated mandibular involvement.
Implications:
- Radiographic appearance of metastatic lesions can be misleading.
- Accurate diagnosis relies on integrating clinical history, immunohistochemistry (IHC), and tumor markers.
- This case underscores the value of a multidisciplinary approach in diagnosing rare oral cavity metastases.
