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Ancestry-Dependent Immunologic and Prognostic Effects Characterize the Prostate Cancer Urinary Proteome.

Annie Ha1,2, Jaron Arbet3,4, Zhuyu Qiu3,4

  • 1Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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Urinary biomarker differences were found between Black and White prostate cancer patients. These findings emphasize the need to account for race and ancestry in developing new diagnostic tools for prostate cancer.

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Area of Science:

  • Biochemistry
  • Oncology
  • Urology

Background:

  • Urine serves as a valuable non-invasive biomarker for monitoring health and diseases, including genitourinary cancers.
  • Urinary composition is influenced by genetic and lifestyle factors, varying across populations.
  • Men of African ancestry face a higher risk of prostate cancer, but the impact on urinary biomarkers is not well understood.

Purpose of the Study:

  • To investigate racial differences in urinary proteomes among localized prostate cancer patients.
  • To determine if race/ancestry influences urinary biomarker profiles relevant to prostate cancer aggressiveness.

Main Methods:

  • Quantitative analysis of urinary proteomes from 329 localized prostate cancer patients (135 White, 194 Black).
  • Statistical analysis controlled for age, prostate-specific antigen (PSA), and clinical Gleason score (cISUP).

Main Results:

  • Identified 110 proteins with significant differences between self-identified Black and White patients.
  • Observed dysregulation in immune pathways.
  • Urinary proteomes of Black patients showed more indicators of aggressive cancer compared to matched White patients.

Conclusions:

  • Race and ancestry significantly impact urinary proteome profiles in prostate cancer patients.
  • Accounting for race- and ancestry-associated differences is crucial for developing accurate urinary biomarkers.
  • Future biomarker development must consider population-specific variations for effective disease monitoring.