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Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer.

Ryan P Englander1,2, Mattia Brugiolo1, Te-Chia Wu1

  • 1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

Biorxiv : the Preprint Server for Biology
|September 2, 2025
PubMed
Summary

Alternative RNA splicing impacts tumor immunity and immunotherapy response in lung cancer. Specific STAT2 intron retention predicts patient response to checkpoint inhibitors, offering potential biomarkers.

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