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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Updated: Sep 9, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Case Report: Polymyxin E-associated reversible leukopenia.

Suxin Wan1, Jia-Quan Zhu2, Lihua Wang3

  • 1Department of Pharmacy, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.

Frontiers in Immunology
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

Polymyxin E, a last-resort antibiotic, may cause leukopenia (low white blood cell count). This case study highlights the importance of monitoring blood counts during treatment to ensure patient safety.

Keywords:
Klebsiella pneumoniaecase reportleukopeniapolymyxinpolymyxin E

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Hematology

Background:

  • Polymyxin E is a critical antibiotic for multidrug-resistant bacterial infections.
  • Adverse effects of polymyxin E include nephrotoxicity and neurotoxicity.
  • Leukopenia is a potential, though less commonly reported, adverse effect.

Observation:

  • A 50-year-old female patient developed leukopenia during treatment for Klebsiella pneumoniae infection.
  • White blood cell counts decreased significantly from 5.65×10^9/L to 0.91×10^9/L.
  • Leukopenia resolved after discontinuing polymyxin E therapy.

Findings:

  • The Naranjo scale indicated a probable association between polymyxin E and leukopenia (score of 7).
  • The WHO-UMC classification also supported a probable causal relationship.
  • This case suggests polymyxin E can induce leukopenia.

Implications:

  • Rigorous monitoring of white blood cell counts is crucial during polymyxin E treatment.
  • Prompt cessation of polymyxin E is recommended upon detecting hematologic abnormalities.
  • This vigilance can mitigate risks associated with polymyxin E-induced leukopenia.