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Updated: Sep 9, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control
María Clara De La Hoz-Romo1,2, Luis Díaz1,2, Javier Gómez-León3
1Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia.
Abstract:
Quorum sensing (QS) regulates virulence factors in bacteria associated with acne vulgaris. Consequently, extracts from marine actinobacteria sourced from Colombian Caribbean sponges and octocorals were screened for quorum quenching (QQ) and anti-biofilm activity. The most promising extract, G12.218 from Promicromonospora sp. CLIVUS-G12218, inhibited QS by 97 % via AI-2 signaling in Vibrio harveyi BB170 and reduced Staphylococcus aureus biofilm by 60 % at 3 mg/L, without cytotoxicity to keratinocytes and fibroblasts. Untargeted metabolomics of QQ active and non-active extracts revealed distinct profiles enriched in terpenoids, phenols, and butenolides, potentially linked to bioactivity. These extracts also exhibited antioxidant capacity (18 ± 0.23 µmol TE/L) and hyaluronidase inhibition up to 72.8 %, suggesting skin-protective properties. These findings highlight the potential of marine actinobacteria as a source of QQ and anti-biofilm agents for acne therapy and skincare.
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