Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

2.2K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.2K
Oxidations of Aldehydes and Ketones to Carboxylic Acids01:15

Oxidations of Aldehydes and Ketones to Carboxylic Acids

4.2K
Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
4.2K
Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

256
Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
256
Autoxidation of Ethers to Peroxides and Hydroperoxides02:23

Autoxidation of Ethers to Peroxides and Hydroperoxides

8.2K
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
8.2K
Curing of Concrete01:20

Curing of Concrete

166
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
166
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids02:04

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

6.1K
Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Purification and concentration of model viruses using single-pass tangential flow filtration.

Biotechnology progress·2026
Same author

Highly oxidation-resistant imidazolium-modified catechol for stable wet adhesion under alkaline conditions.

RSC applied interfaces·2026
Same author

Electrochemical deactivation of high-strength, catechol-based adhesives incorporated with anhydrous proton and electron conducting elements.

Communications materials·2026
Same author

Salicylhydroxamic acid as an electro-responsive and switchable adhesive molecule.

Chemical science·2026
Same author

Unraveling microplastic retention distribution in porous media: A unified framework coupling flow conditions and particle properties.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Protracted core formation and impact disruptions shaped the earliest outer Solar System planetesimals.

Science advances·2025
Same journal

Hybrid Poly(<i>β</i>-amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting-From Methodology.

Macromolecular chemistry and physics·2024
Same journal

Controlling Rheology of Fluid Interfaces through Microblock Length of Sequence-Controlled Amphiphilic Copolymers.

Macromolecular chemistry and physics·2023
Same journal

Degradable Polymer Films Made from Poly(salicylic-acid-<i>co</i>-sebacic acid) and Poly(sebacic anhydride)/Poly(adipic anhydride) Blends: Degradation Kinetics and Use as Sacrificial Layers for Polymer Multilayer Systems.

Macromolecular chemistry and physics·2021
Same journal

Solute Transport Dependence on 3D Geometry of Hydrogel Networks.

Macromolecular chemistry and physics·2021
Same journal

Two-distinct polymer ubiquitin conjugates by photochemical grafting-from.

Macromolecular chemistry and physics·2021
Same journal

Bioinspired All-Polyester Diblock Copolymers Made from Poly(pentadecalactone) and Poly(2-(2-hydroxyethoxy)benzoate): Synthesis and Polymer Film Properties.

Macromolecular chemistry and physics·2021
See all related articles

Related Experiment Video

Updated: Sep 9, 2025

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
09:06

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

7.4K

Autoxidation-Induced Curing of 6-Hydroxycatechol-Containing Adhesive.

Zhongtian Zhang1, Bruce P Lee1

  • 1Department of Biomedical Engineering, Michigan Technological University, Houghton 49931, USA.

Macromolecular Chemistry and Physics
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

Newly developed 6-hydroxydopamine (6-OHDA) modified polyethylene glycol (PEG) biomaterials can rapidly cure via autoxidation, eliminating the need for external oxidants. This advancement offers faster, stronger injectable adhesives for biomedical applications.

Keywords:
6-hydroxycatecholUV-visadhesiveautoxidationcuring

More Related Videos

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.0K
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.1K

Related Experiment Videos

Last Updated: Sep 9, 2025

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
09:06

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

7.4K
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.0K
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.1K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Adhesive Technology

Background:

  • Catechol derivatives are crucial for in-situ curable biomaterials and adhesives.
  • Traditional catechol-based adhesives require external chemical or enzymatic oxidants for rapid curing.

Purpose of the Study:

  • To evaluate the autoxidation-driven curing feasibility of 6-hydroxydopamine (6-OHDA)-modified 8-armed polyethylene glycol (PEG).
  • To investigate the role of the 6-position hydroxyl group in accelerating oxidation and crosslinking.
  • To assess the adhesive strength of the developed biomaterial compared to commercial alternatives.

Main Methods:

  • Modification of 8-arm PEG with 6-OHDA.
  • Evaluation of autoxidation cure kinetics.
  • Addition of polyethyleneimine (PEI) to assess synergistic effects.
  • UV-vis spectroscopy to identify oxidation intermediates.
  • Adhesion testing on pericardium tissues.

Main Results:

  • 6-OHDA-modified PEG (8-arm PEG-DA-OH) cured via autoxidation in just over 1 minute.
  • Cure time reduced to under 40 seconds with PEI addition.
  • UV-vis spectra confirmed deprotonated 6-OHDA quinone as a key crosslinking intermediate with primary amines.
  • Unmodified catechol-PEG did not autoxidize, highlighting the importance of the 6-hydroxyl group.
  • The 8-arm PEG-DA-OH and PEI mixture showed superior adhesion strength compared to DuraSeal®.

Conclusions:

  • 6-OHDA is an effective crosslinking precursor for developing injectable adhesives that cure via autoxidation without external oxidants.
  • The electron-donating hydroxyl group at the 6-position of 6-OHDA significantly enhances oxidation and crosslinking rates.
  • This novel biomaterial offers improved adhesion and simplified activation through aqueous dissolution.