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Open partial or transoral laryngectomy - total laryngectomy today
Dietmar Thurnher1, Ricard Simo2, Giovanni Succo3
1Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria.
Frontiers in Oncology
|September 2, 2025
Summary
Total laryngectomy, the complete removal of the larynx, remains vital for advanced laryngeal cancer. Despite advancements, it offers a critical treatment option when other methods fail, improving patient outcomes.
Area of Science:
- Otolaryngology
- Surgical Oncology
Background:
- Total laryngectomy, first performed in 1873, is a cornerstone treatment for advanced laryngeal cancer.
- Surgical techniques, postoperative care, and rehabilitation have significantly improved over 150 years.
- Organ-preserving treatments like radiochemotherapy are now common, but total laryngectomy remains essential for specific cases.
Purpose of the Study:
- To review the historical evolution and development of total laryngectomy for laryngeal cancer.
- To examine the current role and efficacy of total laryngectomy.
- To compare total laryngectomy with alternative treatments such as partial laryngectomy and organ preservation protocols.
Main Methods:
- Literature review of historical and contemporary studies on total laryngectomy.
- Comparative analysis of surgical outcomes and patient quality of life.
- Evaluation of treatment protocols for advanced laryngeal cancer.
Main Results:
- Total laryngectomy has evolved considerably, enhancing survival rates and patient quality of life.
- Despite the rise of organ-preserving therapies, total laryngectomy remains a viable and necessary option for advanced or refractory laryngeal cancer.
- The procedure's long-term efficacy and role in multimodal treatment strategies are well-established.
Conclusions:
- Total laryngectomy continues to be a critical surgical intervention for advanced laryngeal cancer.
- Ongoing advancements ensure its place in the treatment paradigm, offering hope for improved patient outcomes.
- Comparative analysis supports its use alongside or as an alternative to organ preservation methods.

