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Decrease in SinglePlex Viral PCRs Use and acyclovir utilization following implementation of The BioFire

Tracy McMillen1, Eleanor Powell1,2, Krupa Jani1

  • 1Clinical Microbiology Service, Department of Pathology and Laboratory Medicine, USA.

Journal of Clinical Virology Plus
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

The BioFire Meningitis/Encephalitis (M/E) panel reduced viral PCR tests and acyclovir use in cancer patients. This diagnostic tool improved treatment efficiency for meningitis and encephalitis in this vulnerable population.

Keywords:
AcyclovirCancerEncephalitisMeningitisMultiplex PCRRapid diagnostic tests

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Area of Science:

  • Infectious Disease Diagnostics
  • Oncology
  • Clinical Microbiology

Background:

  • Meningitis and encephalitis are critical medical emergencies.
  • The BioFire Meningitis/Encephalitis (M/E) panel detects 14 pathogens in cerebrospinal fluid (CSF).
  • Limited data exist on the M/E panel's impact in cancer patients.

Purpose of the Study:

  • To evaluate the impact of the M/E panel on antiviral and viral test utilization in cancer patients.
  • To assess changes in acyclovir and singleplex PCR test usage post-implementation.
  • To analyze the M/E panel's effect on treatment duration and patient numbers.

Main Methods:

  • A pre- and post-intervention study design was employed.
  • Data were collected from laboratory and clinical information systems.
  • 476 cancer patients (207 pre-intervention, 269 post-intervention) were analyzed.

Main Results:

  • Singleplex viral PCR tests decreased by 64.9% post-M/E panel implementation.
  • Acyclovir treatment was reduced by 29.1% in the post-intervention group.
  • The duration of acyclovir therapy significantly decreased (p < 0.0274).

Conclusions:

  • The M/E panel implementation reduced singleplex PCR testing in cancer patients.
  • The panel contributed to decreased acyclovir utilization and therapy duration.
  • The BioFire M/E panel optimizes diagnostic and therapeutic approaches for meningitis/encephalitis in cancer patients.