Related Experiment Video
Updated: Sep 9, 2025
09:36
Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
983
Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico
Wen Xin Toh1, Sin Yee Tang2, Kae Shin Sim1
1Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Fitoterapia
|September 2, 2025
Summary
Cytotoxic alkaloids from Malaysian Tabernaemontana polyneura show potential as drug leads. In silico analysis indicates good bioavailability and safety, warranting further pharmacological investigation.
Area of Science:
- Ethnobotany
- Phytochemistry
- Medicinal Chemistry
Background:
- Tabernaemontana species are traditionally used for medicinal purposes.
- Indole alkaloids from this genus exhibit significant cytotoxic properties.
- The Malaysian native T. polyneura remains under-researched.
Purpose of the Study:
- To provide a comprehensive overview of T. polyneura.
- To analyze the phytochemistry of its cytotoxic alkaloids.
- To conduct in silico ADMET analysis of these compounds.
Main Methods:
- Literature search across multiple scientific databases.
- Screening of articles based on inclusion/exclusion criteria.
- Computational pharmacokinetic assessment using SwissADME and ORISIS Data Warrior.
Main Results:
- T. polyneura, found in Malaysia, has 79 known alkaloids, with 16 identified recently.
- 26 cytotoxic alkaloids were assessed.
- In silico analysis indicated compliance with Lipinski's and Veber's rules, with no predicted organ/systemic toxicity.
Conclusions:
- Cytotoxic alkaloids from T. polyneura exhibit promising bioavailability and safety profiles.
- These findings support their potential for further pharmacological research and drug development.
- In vitro and in vivo studies are recommended to validate therapeutic potential.
