Rural and Remote Acute STEMI Diagnosis and Management: Current Status and Future Directions

Ryan Gadeley1, Ruth Arnold2, David Amos2

  • 1Department of Cardiology, Orange Health Service, Orange, NSW, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Heart, Lung & Circulation
|September 2, 2025
PubMed

Insights

For ST-elevation myocardial infarction (STEMI), thrombolysis followed by rescue percutaneous coronary intervention (PCI) is crucial in rural areas lacking immediate PCI facilities. This review assesses current practices and knowledge gaps for this vital treatment approach.

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Rural Health

Background:

  • Current guidelines recommend primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI).
  • Thrombolysis followed by rescue PCI is an alternative when pPCI is delayed beyond 120 minutes.
  • This approach is vital for rural and remote populations where pPCI access is limited.

Purpose of the Study:

  • To review the current status of thrombolysis and rescue PCI in rural and remote settings.
  • To examine changes and identify knowledge gaps in this treatment strategy.
  • To provide an updated evaluation and future outlook for STEMI care in underserved areas.

Main Methods:

  • Literature review of current guidelines and research.
  • Analysis of treatment protocols and outcomes in rural/remote STEMI care.
  • Evaluation of historical changes and persisting challenges in thrombolysis and rescue PCI.

Main Results:

  • Thrombolysis followed by rescue PCI remains a key strategy for STEMI in areas without immediate pPCI.
  • Significant population segments rely on this approach due to geographical limitations.
  • Gaps in knowledge and practice require further investigation and optimization.

Conclusions:

  • Thrombolysis and rescue PCI are essential for equitable STEMI management in rural Australia.
  • Ongoing evaluation and research are needed to improve outcomes for these patients.
  • Future directions should focus on bridging the gap in timely reperfusion therapy.

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