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Identification of the Novel HLA-DQA1*05:121 Allele by Next-Generation Sequencing
Chiara Sindici1, Donatella Londero1
1Lab. di Immunogenetica e RR UD01-IBMDR, Dip. Medicina Trasfusionale Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
HLA
|September 3, 2025
Abstract
None:
The HLA-DQA1*05:121 allele differs from the HLA-DQA1*05:05:01:01 allele by a single nucleotide in exon 3.
Related Concept Videos
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...