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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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NF-κB-dependent Signaling Pathway02:26

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Related Experiment Video

Updated: Sep 9, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy.

Hye Jin Lee1, Yu Jin So1, Il-Joo Jo2

  • 1College of Korean Medicine, Woosuk University, Jeonju-si, Republic of Korea.

Phytotherapy Research : PTR
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

Natural compounds show promise for managing psoriasis by targeting key inflammatory pathways. They offer a potentially safer, adjunctive treatment option to alleviate symptoms and reduce side effects associated with conventional therapies.

Keywords:
abnormalities of immune responsesclinical trialsnatural productspsoriasisskin barrier

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin disease with genetic, immune, and environmental influences.
  • It causes physical discomfort and comorbidities like arthritis and cardiovascular issues, creating significant burdens.
  • Current treatments have limitations, including side effects and dependency.

Purpose of the Study:

  • To review the therapeutic potential of natural compounds for psoriasis.
  • To evaluate their ability to modulate key cellular pathways in psoriasis pathogenesis.
  • To assess their role as a safer, adjunctive treatment option.

Main Methods:

  • Literature review focusing on natural compounds and psoriasis.
  • Analysis of studies investigating natural compounds' effects on inflammatory pathways.
  • Evaluation of anti-inflammatory, keratinocyte-regulating, and antioxidant properties.

Main Results:

  • Natural compounds possess anti-inflammatory, antioxidant, and keratinocyte-regulating properties.
  • They influence critical pathways such as the Th17/IL-17 axis and oxidative stress.
  • Evidence suggests potential for symptom management and side effect mitigation.

Conclusions:

  • Natural compounds may serve as effective adjunctive therapies for psoriasis.
  • They offer a potentially safer alternative by addressing underlying mechanisms.
  • Further research can optimize their use in managing psoriasis symptoms.