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The oral penems and carbapenems
Sena Sayood1, Elizabeth Neuner2, Rebekah Dumm3
1Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Clinical Microbiology Reviews
|September 3, 2025
Summary
New oral penem and carbapenem antibiotics offer broad-spectrum coverage, similar to IV options but with easier administration. Their expanding use in new markets simplifies treatment for various infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Antimicrobial Therapy
Background:
- Penem and carbapenem antibiotics offer broad-spectrum antimicrobial coverage.
- Parenteral administration is typical, limiting accessibility.
- Emerging oral formulations present new therapeutic options.
Purpose of the Study:
- To review the characteristics and applications of newly available oral penem and carbapenem antibiotics.
- To highlight the advantages of oral administration over parenteral routes.
- To discuss the clinical utility and stewardship of these agents.
Main Methods:
- Review of existing literature on oral faropenem, sulopenem, and tebipenem.
- Analysis of pharmacokinetic and pharmacodynamic data.
- Evaluation of clinical efficacy, safety, and stewardship considerations.
Main Results:
- Oral penems (faropenem, sulopenem) and carbapenem (tebipenem) exhibit broad-spectrum activity comparable to parenteral agents.
- These oral antibiotics offer simpler administration compared to intravenous formulations.
- New market approvals are driving increased utilization of these oral agents.
Conclusions:
- Oral penem and carbapenem antibiotics represent a significant advancement in antimicrobial therapy.
- Their ease of administration and broad spectrum make them valuable alternatives.
- Antimicrobial stewardship is crucial for optimizing the use of these potent agents.
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