[Clinical efficiency of polyvalent piobacteriophage in the complex treatment of nosocomial sinusitis]
A I Kryukov1,2, A V Gurov1,2, D S Cherkasov1
1Pirogov Russian National Research Medical University 1, Ostrovityanov St., Moscow, Russia.
Abstract:
The article presents the results of the study of polyvalent pyobacteriophage in the complex therapy of nosocomial sinusitis in 30 patients of intensive care units of a multidisciplinary hospital in Moscow. The etiologic factors of nosocomial sinusitis manifestation were the following microorganisms: Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Acinetobacter nosocomialis, Pseudomonas aeruginosa, Proteus mirabilis, Enterobacter aerogenes. According to the results of the study it was revealed that at the empirical phage therapy the regression of the main clinical symptomatology was achieved in 90% of patients. The average number of days of this therapy before registration of clinical sanation of the maxillary sinus was 4±1.9. Microbiological sanitation of the maxillary sinuses was achieved in 46.7% of cases.
Insights
Polyvalent pyobacteriophage therapy effectively treated nosocomial sinusitis in ICU patients, with 90% showing symptom improvement. This phage therapy offers a promising approach for managing hospital-acquired infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Therapeutics
Context:
- Nosocomial sinusitis is a significant complication in intensive care units.
- Multidrug-resistant bacteria like Klebsiella pneumoniae and Acinetobacter baumannii are common causes.
- Effective treatment options for hospital-acquired infections are urgently needed.
Purpose:
- To evaluate the efficacy of polyvalent pyobacteriophage in the complex therapy of nosocomial sinusitis.
- To assess clinical and microbiological outcomes in intensive care unit (ICU) patients.
Summary:
- A study involving 30 ICU patients with nosocomial sinusitis investigated polyvalent pyobacteriophage therapy.
- Etiologic agents included Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus.
- Empirical phage therapy resulted in clinical symptom regression in 90% of patients within an average of 4 days.
Impact:
- Polyvalent pyobacteriophage demonstrated significant clinical efficacy in treating nosocomial sinusitis.
- Microbiological sanitation was achieved in 46.7% of cases, indicating potential for infection control.
- This study highlights phage therapy as a viable alternative or adjunct treatment for severe hospital-acquired infections.
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