Related Experiment Video
Updated: Sep 9, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
Memory-induced slow relaxation in the generalized Langevin equation
Makoto Shimizu1, Tomoshige Miyaguchi2, Eiji Yamamoto3
1Department of Physics and Astronomy, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
Abstract:
We investigate the relaxation dynamics of the generalized Langevin equation (GLE) with an exponential memory kernel. Our analysis reveals that the relaxation time to equilibrium scales inversely with the square of the memory decay rate λ, i.e., τrelax ∝ λ-2. To understand the origin of this scaling, we analyze the escape dynamics from a potential well and find that the mean escape time follows the same λ-2 dependence. This indicates that the slow relaxation arises from memory-suppressed fluctuations that delay escape events. To explain these findings, we reformulate the GLE using an auxiliary variable, embedding the non-Markovian dynamics in a higher-dimensional Markovian system. This approach provides a clear physical picture of how memory influences noise, diffusion, and relaxation in non-Markovian systems.
Related Concept Videos
Atomic Nuclei: Types of Nuclear Relaxation
In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers...
Atomic Nuclei: Nuclear Relaxation Processes
Relaxation of Skeletal Muscles
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
The Nernst Equation
The interconnection between standard cell potentials and various thermodynamic parameters such as the standard free energy change ΔG° and equilibrium constant K has been previously explored. For example, a redox reaction involving zinc(II) and tin(II) ions at 1 M concentration with Eºcell = +0.291 V and ΔG° = −56.2 kJ is spontaneous.
NMR Spectrometers: Resolution and Error Correction
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

