Ménétrier disease: A clinical review

Area of Science:

• Gastroenterology
• Pathology

Background:

• Ménétrier disease (MD), or hyperplastic hypersecretory gastropathy, is a rare gastric disorder.
• Characterized by gastric mucosal hypertrophy, giant folds, excessive mucus, and protein loss.

Purpose of the Study:

• To review the current understanding of Ménétrier disease.
• To outline diagnostic approaches and therapeutic strategies for MD.

Main Methods:

• Literature review of MD pathogenesis, clinical presentation, diagnosis, and treatment.
• Analysis of studies linking MD to EGFR signaling.

Main Results:

• MD pathogenesis involves excessive transforming growth factor-alpha signaling via EGFR.
• Clinical features include epigastric pain, weight loss, and edema.
• Diagnosis relies on clinical, endoscopic, and histopathological findings.

Conclusions:

• MD requires a comprehensive approach to diagnosis and management.
• Targeted therapies like EGFR inhibitors offer new treatment avenues.
• Further research into MD pathogenesis is warranted.