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Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling.  This phenomenon, called the Nuclear Overhauser Enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring...
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A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles
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Harnessing Energy Enrichment Strategy for Designing Innovative Sandwich-Structured Upconversion Nanoprobes.

Jiawei Zhu1,2, Xiaohui Kang1,3, Jianjun Shen1,3

  • 1Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

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|September 3, 2025
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Summary
This summary is machine-generated.

Novel sandwich-structured upconversion nanoparticles (UCNPs) overcome low quantum yield limitations. These engineered UCNPs exhibit significantly enhanced upconversion luminescence (UCL) intensity, paving the way for highly sensitive biosensing applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Upconversion nanoparticles (UCNPs) offer advantages but suffer from low quantum yield, hindering sensing applications.
  • High luminescence resonance energy transfer (LRET) efficiency and quantum yield are crucial for UCNP-based sensors.

Purpose of the Study:

  • To synthesize novel sandwich-structured UCNPs (SWUCNPs) to address the limitations of low quantum yield and enhance UCL.
  • To improve the performance of UCNPs for highly sensitive detection applications.

Main Methods:

  • Synthesis of NaYbF4:(30%Gd)@NaYbF4:Er(2%)@NaYF4 SWUCNPs with a core-middle shell-outer shell structure.
  • Characterization of SWUCNPs' optical properties, including UCL intensity and LRET efficiency.
  • Demonstration of SWUCNPs in high-sensitivity ascorbic acid detection.

Main Results:

  • The novel SWUCNPs demonstrated significantly boosted UCL intensity (56-fold at 540 nm, 117-fold at 655 nm) compared to traditional SWUCNPs.
  • High LRET efficiency was maintained by confining the Er3+ luminescent center in the middle shell.
  • The engineered core and host lattice enhanced excitation light absorption and energy transfer.

Conclusions:

  • The developed SWUCNP structure effectively enhances UCL intensity and LRET efficiency.
  • This strategy provides a novel pathway for preparing highly sensitive upconversion nanoprobes for various applications.
  • The SWUCNPs show promise for high-sensitivity detection of analytes like ascorbic acid.