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Updated: Jun 20, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
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Lincoln Sign in a Case of Langerhans Cell Histiocytosis on Bone Scintigraphy
Huan Liang1, Ziqian Dong, Feilong Chen
1Department of Nuclear Medicine, The Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, PR China.
Abstract:
Lincoln sign, also known as the black beard sign, is considered the classic manifestation of monostotic Paget disease of the mandible on bone scintigraphy. Here we report the bone scintigraphy findings in a case of Langerhans cell histiocytosis in a 32-year-old man. The images showed intense uptake of MDP in the mandible, which could also be described as the Lincoln sign.
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