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Updated: Sep 9, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

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Advances in therapeutic strategies for acute kidney injury

Shuangyan Song1, Wuyue Su2, Hongbo Wang1

  • 1School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.

Life Sciences
|September 3, 2025
PubMed

Insights

Acute Kidney Injury (AKI) treatments are limited, with supportive care being the norm. This review explores novel therapeutic strategies, including nanomedicine and gene therapy, to repair kidney damage.

Area of Science:

  • Nephrology
  • Translational Medicine
  • Pharmacology

Background:

  • Acute Kidney Injury (AKI) is a critical condition with high mortality.
  • Current AKI treatments are primarily supportive, lacking effective renal repair therapies.
  • Understanding AKI mechanisms is advancing, but clinical interventions lag.

Purpose of the Study:

  • To review recent advancements in Acute Kidney Injury (AKI) therapy.
  • To focus on AKI induced by nephrotoxic drugs, sepsis, and ischemia-reperfusion.
  • To highlight innovative therapeutic strategies and emerging clinical tools.

Main Methods:

  • Literature review of recent progress in AKI therapy.
  • Focus on specific AKI causes: nephrotoxic drugs, sepsis, ischemia-reperfusion.
  • Discussion of novel approaches: nanomedicine, plant-derived therapeutics, ferroptosis inhibition, gene/microRNA targeting.

Main Results:

  • Several innovative therapeutic strategies show promise for AKI.
  • Nanomedicine, plant-derived compounds, ferroptosis inhibitors, and gene-based therapies are emerging.
  • New clinical interventions and assessment tools are under development.

Conclusions:

  • Effective therapies to reverse or repair AKI remain a critical unmet need.
  • Innovative strategies like nanomedicine and gene therapy offer potential for AKI treatment.
  • Bridging experimental research and clinical application is crucial for improving AKI outcomes.
Keywords:
Acute kidney injuryIschemia-reperfusion injuryNephrotoxicitySepsisTherapeutic strategy

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