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Updated: Sep 9, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
NSs: the multifaceted bunyavirus virulence factor
Maëva Duboeuf1, Anne-Flore Legrand1, Pierre-Yves Lozach2
1IVPC UMR754, INRAE, Universite Claude Bernard Lyon 1, EPHE, Université PSL, Lyon, France.
Abstract:
Bunyaviricetes represents a diverse class of RNA viruses, including hundreds of species distributed worldwide that threaten human and animal health. This Perspective briefly overviews bunyaviruses infecting humans and other mammals, focusing on their key virulence factor, the nonstructural protein NSs. By subverting host cell processes, NSs promotes immune evasion and viral replication. Here, we discuss its role in bunyavirus cytotoxicity and virulence and highlight its implications for pathogenesis.
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