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Can Photobiomodulation Reverse the Effects of Botulinum Toxin?

Wilson Gustavo Cral1

  • 1Centro Universitario do Distrito Federal, Brasilia, Brazil. wgcral@gmail.com.

Aesthetic Plastic Surgery
|September 3, 2025
PubMed
Summary

Photobiomodulation, or low-level laser therapy, may reverse undesirable effects of botulinum toxin type A. This novel approach offers a potential solution for patient dissatisfaction with cosmetic treatments.

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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