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Effects of Roller Compaction on Dissolution of Granules and Tablets Captured in the Development of Two Real

Nikita Marinko1,2, Stephanie Michelle Medrano3,4, Tomáš Krpelan3

  • 1Department of Organic Technology, Faculty of Chemical Technology, University of Chemistry and Technology, Technická 5, 166 28, Prague, Czech Republic. nikita.marinko@zentiva.com.

AAPS Pharmscitech
|September 3, 2025
PubMed

Keywords:
Disintegration kineticsDissolution behaviorDissolution rateDry granulationFlow-through cellGranule dissolutionGranule propertiesPaddle dissolutionPoller compactionPorosityProcess engineeringProcess parametersTablet dissolutionUSP2 dissolutionUSP4 dissolution

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