Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

383
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
383
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

409
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
409
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

667
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
667
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

209
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
209
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

340
The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
340
Pharmacodynamic Models: Additive and Proportional Drug Effect Model01:09

Pharmacodynamic Models: Additive and Proportional Drug Effect Model

41
Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
41

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Roller Compaction on Dissolution of Granules and Tablets Captured in the Development of Two Real Pharmaceutical Formulations.

AAPS PharmSciTech·2025
Same author

Development of an Image-based Method for Tablet Microstructure Description and Its Correlation with API Release Rate.

AAPS PharmSciTech·2023
Same author

Co-Pyrolysis of Unsaturated C4 and Saturated C6+ Hydrocarbons-An Experimental Study to Evaluate Steam-Cracking Performance.

Materials (Basel, Switzerland)·2023
Same author

Dissolution Kinetics of Meloxicam Formulations Co-Milled with Sodium Lauryl Sulfate.

Pharmaceutics·2022
Same author

Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor in Powder Flow and Compaction Applications.

Materials (Basel, Switzerland)·2021
Same author

Meloxicam Carrier Systems Having Enhanced Release and Aqueous Wettability Prepared Using Micro-suspensions in Different Liquid Media.

AAPS PharmSciTech·2020

Related Experiment Video

Updated: Mar 1, 2026

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.7K

Modelling of Rheological Properties of Pharmaceutical Powder Mixtures for Direct Compression: A Statistical Approach.

Pavlína Komínová1, Michaela Gajdošová2, David Smrčka2

  • 1Department of Organic Technology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic. pavlina.kominova@vscht.cz.

AAPS Pharmscitech
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Predicting pharmaceutical mixture rheology is complex. This study developed models using component properties to accurately forecast blend flowability, aiding formulation development and direct compression processes.

Keywords:
formulation developmentmultilinear regression analysisparticulate systemspowder rheometerrheological properties

More Related Videos

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K
Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes
08:42

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Published on: April 10, 2017

20.6K

Related Experiment Videos

Last Updated: Mar 1, 2026

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.7K
Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K
Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes
08:42

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes

Published on: April 10, 2017

20.6K

Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Chemical Engineering

Background:

  • Rheological properties of pharmaceutical mixtures are critical for product quality but difficult to predict.
  • Existing methods lack a universally applicable approach to define and control mixture rheology due to complex particulate behavior.

Purpose of the Study:

  • To develop an approach for evaluating and predicting the flow properties of binary particulate mixtures.
  • To guide formulation development by predicting mixture rheology from individual component parameters.

Main Methods:

  • Investigated powder flowability parameters under various stress levels using the FT4 powder rheometer.
  • Studied mixtures of ibuprofen (model API) with common fillers.
  • Developed multilinear regression models incorporating critical parameters, composition, and particle characteristics.

Main Results:

  • Mixture rheological behavior is condition-dependent and not a simple additive combination of component properties.
  • Multilinear regression models effectively predicted mixture behavior by accounting for complex interdependencies.
  • Prediction models are valid for ibuprofen and similar active pharmaceutical ingredients (APIs).

Conclusions:

  • Developed models can streamline the selection of suitable mixtures for direct compression.
  • The approach helps identify and address potentially problematic rheological aspects in pharmaceutical blends.
  • Accurate prediction of mixture rheology is achievable by considering complex particle interactions.