[The nature of interactions between total histones and membranes of isolated lysosomes]

Total fraction of histones increased the permeability of isolated lysosomes as showed the elevation in nonsedimented and free enzymatic activity of the matrix. S-like shape of curves, observed in dose-dependent effect of the histones increased concentrations on the enzymatic activity, indicated the structure transformations of membranes occurring by the cooperative type. Membranotropic effect of histones exceeded the action on non-ionic detergent Triton X-100. Hydrophobic interactions of histones with lysosomal membranes appear to be responsible for the effects observed.