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Structure Elucidation and Complete NMR Spectral Assignments of New Sesquiterpenes Isolated From Marine Derived Fungus
Baorui Teng1, Sijing Liu2, Dan Zhang1
1School of Pharmacy, Southwest Medical University, Luzhou, China.
Abstract:
Six sesquiterpene derivative compounds (1-6), including one new 7R-sydowic acid (1) and five known compounds (2-6) were isolated from the secondary metabolites of Aspergillus sydowii-HB. The structures were determined by NMR spectroscopy and ESI-MS analysis, and the configuration of compound 1 was confirmed through DP4+ calculation and NMR chemical shift. All the isolated compounds (1-6) were tested for their cytotoxic activities. The possible biosynthetic pathways for compounds (1-6) were also postulated.
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