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Updated: Sep 9, 2025

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Synchronous yet distinct HPV-associated sinonasal carcinomas on an immune-dysfunctional background.

Jerin Thomas1,2, Peter Giannaris1,2, Kelly Lee1,2

  • 1Department of Otolaryngology-Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra University, Hempstead, NY 11549, United States.

Journal of Surgical Case Reports
|September 4, 2025
PubMed
Summary

This study details a rare human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma (HMSC) case. The patient had two distinct tumors driven by HPV45, a novel finding for HMSC.

Keywords:
HPV-associated multiphenotypic sinonasal carcinomahead and neck cancerhuman papillomavirusimmune dysfunctionsinonasal cancer

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