Global respiratory tumor mortality correlation study with economic level, 2000-2019

Area of Science:

• Global Health Epidemiology
• Economic Impact of Cancer
• Respiratory Oncology

Background:

• Lung cancer remains a significant global health challenge.
• Understanding the socioeconomic determinants of lung cancer mortality is crucial for effective public health interventions.
• Previous research has explored various risk factors, but the relationship with national economic levels requires further investigation.

Purpose of the Study:

• To investigate the correlation between global tracheobronchial lung cancer mortality rates and national economic levels.
• To assess the regional economic burden associated with lung cancer mortality.
• To inform global health resource allocation and cancer control strategies.

Main Methods:

• Analysis of World Health Organization (WHO) mortality data (ICD-10 codes C33-C34) from 2000-2019.
• Calculation of age-standardized mortality rates (ASMRs) to assess spatiotemporal trends.
• Non-parametric (Wilcoxon rank-sum) and correlation (Spearman's partial rank) analyses to examine gender and income associations.

Main Results:

• Global ASMR for respiratory cancers exhibited a decreasing trend between 2000 and 2019.
• A significant positive correlation was found between national income levels and respiratory cancer mortality (Spearman's ρ = 0.422, p < 0.001).
• ASMRs were consistently higher in males than females (Wilcoxon rank-sum test, p < 0.001).

Conclusions:

• Global lung cancer mortality shows a positive association with national economic level, particularly in high- and middle-income countries.
• Males exhibit significantly higher mortality rates compared to females.
• Economic development may paradoxically increase respiratory cancer mortality, necessitating balanced, income-tailored prevention strategies.