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Updated: Sep 9, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

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Exploring the Radical Addition to Sydnones: A Gateway to Perfluoroalkyl-Substituted Pyrazoles

Zakhar M Rubanov1, Denis S Koltun1, Vitalij V Levin1

  • 1N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospekt 47, Moscow 119991, Russian Federation.

Organic Letters
|September 4, 2025
PubMed
Summary

This study introduces a novel method for directly adding perfluoroalkyl groups to sydnones, creating fluorinated compounds. These compounds are then used to synthesize important perfluoroalkylated pyrazoles for medicinal chemistry.

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