Patient-Reported Paresthesia After Administration of Suzetrigine: A Case Report

Area of Science:

• Pharmacology
• Clinical Medicine
• Pain Management

Background:

• Suzetrigine is a novel, first-in-class non-opioid analgesic.
• It is indicated for moderate to severe acute pain, particularly postoperative pain.
• Initial clinical trials reported headache and constipation as common side effects.

Purpose of the Study:

• To report a previously undocumented side effect of suzetrigine.
• To highlight potential adverse events with wider post-marketing drug use.
• To describe a case of paresthesia in a patient receiving suzetrigine.

Main Methods:

• Case report presentation.
• Review of patient's medical history and drug administration.
• Clinical observation and documentation of adverse events.

Main Results:

• The patient experienced paresthesia after suzetrigine administration for refractory postoperative pain.
• This side effect was not identified in pre-marketing clinical trials.
• No other unanticipated problems were reported in initial post-marketing surveillance.

Conclusions:

• Wider clinical use of suzetrigine may reveal additional side effects.
• Paresthesia is a potential adverse event associated with suzetrigine.
• Continued pharmacovigilance is crucial for novel analgesics like suzetrigine.